发明申请
US20060233758A1 Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
审中-公开
针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性
- 专利标题： Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
- 专利标题（中）： 针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性
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申请号： US11274885申请日： 2005-11-16
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公开(公告)号： US20060233758A1公开(公告)日： 2006-10-19
- 发明人: Pierre-Francois Tosi , Claudie Madoulet , Claude Nicolau , David Hickman
- 申请人： Pierre-Francois Tosi , Claudie Madoulet , Claude Nicolau , David Hickman
- 优先权： FR0309188 20030725
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K9/127 ; C12N5/06 ; A61K48/00 ; C07K16/30 ; G01N33/574
摘要：
The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
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