发明申请
US20060252672A1 Protein N-glycosylation of eukaryotic cells using dolichol-linked oligosaccharide synthesis pathway, other N-gylosylation-increasing methods, and engineered hosts expressing products with increased N-glycosylation
审中-公开
使用二烯醇连接的寡糖合成途径，其他N-甲氧基化增加方法的真核细胞的蛋白质N-糖基化和表达具有增加的N-糖基化的产物的工程改造的宿主
- 专利标题： Protein N-glycosylation of eukaryotic cells using dolichol-linked oligosaccharide synthesis pathway, other N-gylosylation-increasing methods, and engineered hosts expressing products with increased N-glycosylation
- 专利标题（中）： 使用二烯醇连接的寡糖合成途径，其他N-甲氧基化增加方法的真核细胞的蛋白质N-糖基化和表达具有增加的N-糖基化的产物的工程改造的宿主
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申请号： US11397907申请日： 2006-04-05
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公开(公告)号： US20060252672A1公开(公告)日： 2006-11-09
- 发明人: Michael Betenbaugh , Karthik Viswanathan , Sharon Krag , Jullian Jones
- 申请人： Michael Betenbaugh , Karthik Viswanathan , Sharon Krag , Jullian Jones
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K48/00
摘要：
The level of glycosylation on products produced by a host (such as CHO cells, HEK cells and other mammalian cells, and non-mammalian cells) or patient can be increased by engineering, such as by supplying the host or patient with a gene sequence. For example, the host or patient can be made to produce desirably glycosylated products by increasing one or both of expression of N-glycan substrate containing lipid-liked oligosaccharide and expression of oligosaccharide (OST) transferase.
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