发明申请
- 专利标题： Osteopontin-based cancer therapies
- 专利标题（中）： 基于骨桥蛋白的癌症治疗
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申请号： US11272528申请日： 2005-11-10
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公开(公告)号： US20060252684A1公开(公告)日： 2006-11-09
- 发明人: Georg Weber
- 申请人： Georg Weber
- 专利权人： New England Medical Center Hospitals, Inc., a Massachusetts corporation
- 当前专利权人： New England Medical Center Hospitals, Inc., a Massachusetts corporation
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K38/54
摘要：
The invention relates to therapies for treating cancer patients by targeting the osteopontin isoforms OPN-b and OPN-c. Osteopontin is a cytokine that is essential for cellular immunity, particularly through its full length form, OPN-a. OPN-b and OPN-c are splice variants that lack exons 5 and 4, respectively, of the protein's six translated exons. The invention provides methods for treating cancer patients with therapeutics that inhibit or degrade the OPN-b or OPN-c isoforms specifically, thereby leaving the innocuous OPN-a form intact and available to perform its normal functions in the cell.
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