发明申请
- 专利标题： Oligomeric compounds and compositions for use in modulation of pri-mirnas
- 专利标题（中）： 低分子化合物和用于调制前视镜的组合物
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申请号： US11329992申请日： 2006-01-10
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公开(公告)号： US20060252722A1公开(公告)日： 2006-11-09
- 发明人: Bridget Lollo , Ravi Jain
- 申请人： Bridget Lollo , Ravi Jain
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02
摘要：
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of pri-miRNAs. In particular, methods and compounds are provided for the modulation of the levels, expression, processing or function of polycistronic pri-miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and pri-miRNAs. Further provided are methods for selectively modulating pri-miRNA levels in a cell. Also provided are methods for identifying oligomeric compounds that result in increase pri-miRNA levels when contacted with a cell.
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