发明申请
US20060252931A1 New CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
有权
新的CGRP拮抗剂，其制备方法及其作为药物组合物的用途
- 专利标题： New CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
- 专利标题（中）： 新的CGRP拮抗剂，其制备方法及其作为药物组合物的用途
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申请号： US11277177申请日： 2006-03-22
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公开(公告)号： US20060252931A1公开(公告)日： 2006-11-09
- 发明人: Stephan Mueller , Klaus Rudolf , Philipp Lustenberger , Dirk Stenkamp , Marco Santagostino , Fabio Paleari , Gerhard Schaenzle , Kirsten Arndt , Henri Doods
- 申请人： Stephan Mueller , Klaus Rudolf , Philipp Lustenberger , Dirk Stenkamp , Marco Santagostino , Fabio Paleari , Gerhard Schaenzle , Kirsten Arndt , Henri Doods
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim
- 优先权： EP05021283 20050929; WOPCT/EP05/04104 20050418; WOPCT/EP05/03094 20050323; AR050101139 20050323; PE000336-2005/OIN 20050323
- 主分类号： C07D498/02
- IPC分类号： C07D498/02 ; C07D491/10 ; C07D487/10 ; C07D403/02
摘要：
The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
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