Systems and methods for determining the integrity of an endoscope. The systems and methods provide for an air enclosure which includes the internal area of the sleeve or tubing of the endoscope to be pressurized. Pressure measurements of the air enclosure are then taken both before and after the endoscope is manipulated by a user. The systems and methods may also or alternatively vent air from inside the endoscope to a humidity detector to detect the presence of fluid inside the endoscope.