发明申请
US20060257423A1 Intracutaneous injection combined vaccine included hevac and bcg for and preparation method
有权
肠内注射联合疫苗包括hevac和bcg及其制备方法
- 专利标题： Intracutaneous injection combined vaccine included hevac and bcg for and preparation method
- 专利标题（中）： 肠内注射联合疫苗包括hevac和bcg及其制备方法
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申请号： US10559471申请日： 2004-05-26
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公开(公告)号： US20060257423A1公开(公告)日： 2006-11-16
- 发明人: Lijie Jin , Zhi Wang , Xiaolin Zhao , Lihua Yang , Wange Chen , Aidong Yu , Junye Sun , Fuxue Zou , Yanming Liu , Aihong Liu , Lihong Yu , Yan Cai , Manlun Yu , Yuwu Wang , Changjun Zhou , Tong Yang , Dejuan Li , Xuan Luo , Li Li
- 申请人： Lijie Jin , Zhi Wang , Xiaolin Zhao , Lihua Yang , Wange Chen , Aidong Yu , Junye Sun , Fuxue Zou , Yanming Liu , Aihong Liu , Lihong Yu , Yan Cai , Manlun Yu , Yuwu Wang , Changjun Zhou , Tong Yang , Dejuan Li , Xuan Luo , Li Li
- 优先权： CN03127065.4 20030606
- 国际申请： PCT/CN04/00534 WO 20040526
- 主分类号： A61K39/295
- IPC分类号： A61K39/295
摘要：
The present invention provides a combined vaccine that includes hepatitis B vaccine (HeVac) and Bacille Calmette-Guerin (BCG) for intracutaneous injection and the method of preparation of such vaccine. The combined vaccine changes the now used liquid agent of the HeVac into a cryoprotectant, thus improving the heat stability of the HBsAg. Because of the cryoprotectant in the combined vaccine, the heat stability of the HBsAg is improved, and the efficacy of the vaccine is only slightly decreased after 30 days at 37° C., and the decrease is lower than with the liquid agent of the HeVac. The present invention changes the newborn's inoculation from two injections into one to simultaneously obtain prophylaxis of hepatitis B and tuberculosis.