- 专利标题: Triazole compounds useful as protein kinase inhibitors
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申请号: US11492450申请日: 2006-07-25
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公开(公告)号: US20060258658A1公开(公告)日: 2006-11-16
- 发明人: David Bebbington , Ronald Knegtel , Hayley Binch , Julian Golec , Pan Li , Jean-Damien Charrier
- 申请人: David Bebbington , Ronald Knegtel , Hayley Binch , Julian Golec , Pan Li , Jean-Damien Charrier
- 主分类号: C07D403/14
- IPC分类号: C07D403/14 ; A61K31/53 ; A61K31/497 ; A61K31/506
摘要:
This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
公开/授权文献
- US07951820B2 Triazole compounds useful as protein kinase inhibitors 公开/授权日:2011-05-31
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