Improved wire guide devices having distal anchoring devices and methods of them percutaneously are provided. One device includes a wire guide having a distal portion operatively coupled to a holding body having a self-expanding end portion having wire members capable of assuming a first radially compressed configuration and a second radially expanded resilient configuration. Another device includes a wire guide distal portion operatively coupled to a distal anchoring device having a distal self-expanding suspension portion having a plurality of stabilizers capable of assuming a first radially compressed configuration when constrained by the outer sheath and a second radially expanded resilient configuration when the sheath is withdrawn proximally. An elongate outer sheath with first and second openings defining a lumen therebetween and slideably constrain the self-expanding portions to the compressed configuration. Expanded configurations help keep the wire guide distal portion at a target site within a body lumen.