A method of fabricating a spherical cavitation chamber is provided. Depending upon the chamber's composition and wall thickness, chambers fabricated with the disclosed techniques can be used with either low or high pressure systems. During chamber fabrication, initially two spherical half portions are fabricated and then the two half portions are joined together to form the desired cavitation chamber. During the fabrication of each chamber half, the interior spherical surface is completed first and then the outer spherical surface. Prior to joining the two spherical cavitation chamber halves, the surfaces to be mated are finished, preferably to a surface flatness of at least ±0.01 inches. Electron beam welding is used to join the chamber halves together. Preferably the electron beam welding operation is performed under vacuum conditions. During electron beam welding, the two chamber halves are aligned and held together while the electron beam forms a weld along the chamber seam.