An hourglass-shaped cavitation chamber is provided. The chamber is comprised of two large cylindrical regions separated by a smaller cylindrical region. Coupling the regions are two transitional sections which are preferably smooth and curved. The chamber can be fabricated from either a fragile material, such as a glass, or a machinable material, such as a metal. A ring-shaped acoustic driver is coupled to one end of the cavitation chamber, preferably using an epoxy or other adhesive. If desired, a second ring-shaped acoustic driver can be coupled to the second chamber end. Coupling conduits which can be used to fill/drain the chamber as well as couple the chamber to a degassing and/or circulatory system can be attached to one, or both, ends of the chamber.