Systems and methods for transparent wireless bridging of communication channels are provided. A plurality of wireless bridge devices are each deployed on a wired communication channel segment and listen for traffic to build a table of MAC addresses for the network devices on each respective segment. The bridges also collectively form a wireless mesh network and publish the MAC addresses on the wireless mesh network so each bridge receives MAC address information for every segment. Accordingly, a sending device on a first segment sends a communication to a target device on a second segment. The respective first bridge passes the communication along through the wireless mesh network to the respective second bridge and the first bridge also sends an acknowledgement to the sending device on behalf of the target device. This proxy acknowledgement allows the wireless bridge system to account for potential latency over the wireless mesh network while at the same time complying with latency requirements and meeting or exceeding the overall round-trip time for network communications.