发明申请
US20060275376A1 Microcapsules with modified release of active principles with low solubility for oral delivery
审中-公开
具有改进释放活性成分的微胶囊，具有低溶解性用于口服递送
- 专利标题： Microcapsules with modified release of active principles with low solubility for oral delivery
- 专利标题（中）： 具有改进释放活性成分的微胶囊，具有低溶解性用于口服递送
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申请号： US10522234申请日： 2003-07-28
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公开(公告)号： US20060275376A1公开(公告)日： 2006-12-07
- 发明人: Florence Guimberteau , Catherine Castan , Remi Meyrueix , Gerard Soula
- 申请人： Florence Guimberteau , Catherine Castan , Remi Meyrueix , Gerard Soula
- 优先权： FR02/09530 20020726
- 国际申请： PCT/FR03/02384 WO 20030728
- 主分类号： A61K9/50
- IPC分类号： A61K9/50 ; A61K9/16
摘要：
The invention concerns microcapsules for reliably modified release and adapted to industrial reproduction of an active principle hardly water-soluble, other than anti-hyperglycemia agents Each of said microcapsules comprises a core of hardly soluble active principle and a coating film applied on the core. Their mean diameter is less than 1000 microns. The coating film contains a film-forming polymer (P1) insoluble in gastrointestinal tract fluids, a water-soluble polymer (P2), a plasticizer (PL), and optionally a lubricating surfactant (TA). Said coating film represents at least 4% p/p of dry mraner of their total weight. and its components P1, P2. PL satisfy the following characteristics: dry weight mass fraction of PI relative to the total coating weight ranging between 40 and 90%; dry matter weight fraction of PL/P1+P2 ranging between 15 and 60%: dry matter weight fraction of PL/P1+P2 ranging between 1 and 30%. The invention also concerns the uses of said microcapsules in galenic formulation.
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