发明申请
US20060276408A1 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
失效
β-β模拟物及其作为生物活性肽或蛋白质抑制剂的用途
- 专利标题： Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
- 专利标题（中）： β-β模拟物及其作为生物活性肽或蛋白质抑制剂的用途
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申请号： US11448412申请日： 2006-06-07
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公开(公告)号： US20060276408A1公开(公告)日： 2006-12-07
- 发明人: Michael Kahn , Cyprian Ogbu , Masakatsu Eguchi , Hwa-Ok Kim , Patrick Boatman
- 申请人： Michael Kahn , Cyprian Ogbu , Masakatsu Eguchi , Hwa-Ok Kim , Patrick Boatman
- 申请人地址： US UT Salt Lake City
- 专利权人： Myriad Genetics, Incorporated
- 当前专利权人： Myriad Genetics, Incorporated
- 当前专利权人地址： US UT Salt Lake City
- 主分类号： A61K38/05
- IPC分类号： A61K38/05 ; A61K38/04 ; A61K31/503 ; A61K31/4162 ; C07D487/04
摘要：
There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the β-sheet mimetic is a thrombin inhibitor.