A first frame has a U-shaped cross section and includes first and second bent portions, and an X-axis actuator is mounted at a specified position of the outer surface of the first bent portion. A second frame has a U-shaped cross section and includes first and second bent portions, and a Y-axis actuator is mounted at a specified position of the outer surface of the first bent portion. A Z-axis actuator is mounted at a suitable position of one end surface of an image pickup unit with respect to X-axis direction. The second frame is disposed between the first and second bent portions of the first frame, and the image pickup unit is disposed between the first and second bent portions of the second frame. The image pickup unit is made movable along three axial directions by the respective actuators. There can be provided a dust removing device and a photographing apparatus with which a clear image having no or little influence of dust can be obtained even if the dust is attached to an image pickup unit and the like.