发明申请
- 专利标题： 1,2-di(cyclic) substituted benzene derivatives
- 专利标题（中）： 1,2-二（环）取代苯衍生物
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申请号： US11453194申请日： 2006-06-14
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公开(公告)号： US20060281747A1公开(公告)日： 2006-12-14
- 发明人: Tetsuya Kawahara , Makoto Kotake , Naoki Yoneda , Shinsuke Hirota , Masayoshi Ohkuro
- 申请人： Tetsuya Kawahara , Makoto Kotake , Naoki Yoneda , Shinsuke Hirota , Masayoshi Ohkuro
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 优先权： JP2005-174072 20050614
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/496 ; A61K31/4747 ; A61K31/4439 ; C07D413/14 ; C07D403/02
摘要：
A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action and cell infiltration inhibitory action. wherein R10 represents 5- to 10-membered cycloalkyl etc. optionally substituted with hydroxyl etc., R30, R31 and R32 may be the same or different and each represents hydrogen etc., R40 represents C1-10 alkyl etc. optionally substituted with hydroxyl etc., n represents an integer of 0, 1 or 2, X1 represents CH or nitrogen, and R20, R21, R22 and R23 may be the same or different and each represents hydrogen etc.