A method of image information enhancement in radiography relates to image information processing techniques in radiography. The method comprising steps of: normalizing an acquired image A(x,y) to form a normalized image B(x,y); filtering the normalized image B(x,y) by a low-pass filter to obtain an filtered image C(x,y); calculating a relative standard deviation for each pixel in the image A(x,y), three times the relative standard deviation being an edge threshold for each pixel; thresholding a difference image obtained by subtracting the filtered image C(x,y) from the normalized image B(x,y) by using the edge threshold for each pixel to form a threshold-processed image D(x,y); enhancing a contrast of the threshold-processed image D(x,y) by using a non-linear function to form a contrast-enhanced image E(x,y); determining a enhancement coefficient a(x,y); obtaining a edge-enhanced image F(x,y) by multiplying the enhancement coefficient a(x,y), the contrast-enhanced image E(x,y) and the filtered image C(x,y); and generating a resulting image by multiplying a sum of the edge-enhanced image F(x,y) and the filtered image C(x,y) with the maximum value Amax As compared with the prior arts, the inventive method has a fast processing speed for image information enhancement and a simple algorithm, images clearly, eliminates noises in the images, and satisfies the requirements of relatively more enhancement to the contrast of the dark regions in the scanned images.