- 专利标题: Fusion proteins for prodrug activation
-
申请号: US11135155申请日: 2005-05-23
-
公开(公告)号: US20060292139A1公开(公告)日: 2006-12-28
- 发明人: Mathias Gehrmann , Gerhard Seemann , Klaus Bosslet , Jorg Czech
- 申请人: Mathias Gehrmann , Gerhard Seemann , Klaus Bosslet , Jorg Czech
- 申请人地址: DE Frankfurt am Main
- 专利权人: Aventis Pharma Deutschland
- 当前专利权人: Aventis Pharma Deutschland
- 当前专利权人地址: DE Frankfurt am Main
- 优先权: DEP4233152.8 19921002
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/12
摘要:
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.
公开/授权文献
- US07273727B2 Fusion proteins for prodrug activation 公开/授权日:2007-09-25