A wireless communication receiver receiving a multiplexed signal comprising two or more signal streams calculates a received signal quality for the multiplexed signal as a function of stream-specific received signal qualities, determines one or more loss parameters indicative of variations in the stream-specific received signal qualities, and generates quality feedback based on such information. In turn, a transmitter controls the selection of one or more transmission parameters of the multiplexed signal based on the quality feedback, such that its transmit link adaptations account for the losses in received signal quality at the receiver arising from the variations in the stream-specific received signal qualities. The quality feedback may include calculated loss values, or parameter/penalties that permit loss calculation, and the method applies to both code multiplexing and spatial multiplexing.