A method and system for correcting defective pixels of a color image, which first performs an interpolation on a Bayer image captured by an image sensor to thus reconstruct red, green and blue (RGB) colors corresponding to each pixel and obtain an RGB image, then converts the RGB image from the RGB domain to a chroma domain, and finally uses neighboring pixel values to correct a respective defective pixel. Because a defective pixel can be distinct from the chroma domain easier than the RGB domain, it can accurately determine whether or not a pixel to be processed is defective.