发明申请
- 专利标题: Bicyclic tetrahydrofuran lactone derivatives and process for the preparation thereof
- 专利标题(中): 双环四氢呋喃内酯衍生物及其制备方法
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申请号: US11303125申请日: 2005-12-15
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公开(公告)号: US20070010679A1公开(公告)日: 2007-01-11
- 发明人: Yong Cho , Joo Cha , Ae Pae , Hun Koh , Chul Shin
- 申请人: Yong Cho , Joo Cha , Ae Pae , Hun Koh , Chul Shin
- 专利权人: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- 优先权: KR10-2005-0061706 20050708
- 主分类号: C07D493/02
- IPC分类号: C07D493/02
摘要:
The present invention relates to bicyclic tetrahydrofuran lactone derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenic acid derivatives in the presence of a phenyl halide, a palladium catalyst and a base: wherein n is 1 or 2, and R is phenyl optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, hydroxyl or C1-C6 hydroxyalkyl group.