发明申请
- 专利标题： Primary rat hepatocyte toxicity modeling
- 专利标题（中）： 原代大鼠肝细胞毒性建模
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申请号： US10357507申请日： 2003-02-04
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公开(公告)号： US20070015147A1公开(公告)日： 2007-01-18
- 发明人: Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Orr , Michael Elashoff
- 申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Orr , Michael Elashoff
- 专利权人： Gene Logic, Inc.
- 当前专利权人： Gene Logic, Inc.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G06F19/00 ; G01N33/48 ; G01N33/50
摘要：
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
公开/授权文献
- US07469185B2 Primary rat hepatocyte toxicity modeling 公开/授权日：2008-12-23
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