Disclosed is a pre-emphasis circuit including a first parallel-to-serial converter, a second parallel-to-serial converter, a mixing circuit and a clock generating circuit. The first parallel-to-serial converter converts parallel data into first serial data, and the second parallel-to-serial converter converts the parallel data into second serial data. The mixing circuit receives the first serial data from the first parallel-to-serial converter and the second serial data from the second parallel-to-serial converter to output a signal emphasizing a change point of the first serial data. The clock generating circuit outputs a first set of clocks made up of clocks having mutually different phases and a second set of clocks made up of clocks having mutually different phases to the first and second parallel-to-serial converters, respectively. The first phase clock of the second set of clocks corresponds to the second phase clock of the first set of clocks.