发明申请
- 专利标题： Methods of treating nervous disorders
- 专利标题（中）： 治疗神经障碍的方法
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申请号： US11190070申请日： 2005-07-27
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公开(公告)号： US20070027146A1公开(公告)日： 2007-02-01
- 发明人: Laurent Desire , Bertrand Leblond , Eric Beausoleil , Thierry Taverne , Fabien Schweighoffer
- 申请人： Laurent Desire , Bertrand Leblond , Eric Beausoleil , Thierry Taverne , Fabien Schweighoffer
- 申请人地址： FR Paris
- 专利权人： EXONHIT THERAPEUTICS SA
- 当前专利权人： EXONHIT THERAPEUTICS SA
- 当前专利权人地址： FR Paris
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61K31/5377 ; A61K31/496 ; A61K31/4709
摘要：
The invention relates to compositions and methods for treating nervous disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1 inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloïd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac1.