发明申请
US20070031399A1 Use of proline specific endoproteases to hydrolyse peptides and proteins
有权
使用脯氨酸特异性内切蛋白酶水解肽和蛋白质
- 专利标题： Use of proline specific endoproteases to hydrolyse peptides and proteins
- 专利标题（中）： 使用脯氨酸特异性内切蛋白酶水解肽和蛋白质
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申请号： US10572811申请日： 2004-09-23
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公开(公告)号： US20070031399A1公开(公告)日： 2007-02-08
- 发明人: Luppo Edens , Melissa Harvey , Robertus Antonius Hoeven
- 申请人： Luppo Edens , Melissa Harvey , Robertus Antonius Hoeven
- 优先权： EP03078012.6 20030923; EP03078496.1 20031106
- 国际申请： PCT/EP04/10782 WO 20040923
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; C12P21/06 ; C12N9/48 ; A61K38/05
摘要：
The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
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