发明申请
US20070031859A1 Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
审中-公开
用于产生具有预先选择的免疫型和/或基因型的纯合干细胞群的方法，适用于从其衍生的移植的细胞，以及使用其的材料和方法
- 专利标题： Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
- 专利标题（中）： 用于产生具有预先选择的免疫型和/或基因型的纯合干细胞群的方法，适用于从其衍生的移植的细胞，以及使用其的材料和方法
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申请号： US11393820申请日： 2006-03-31
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公开(公告)号： US20070031859A1公开(公告)日： 2007-02-08
- 发明人: Wen Yan , Steve Huang , Minh-Thanh Nguyen , Hua (Helen) Lin , Jingqi Lei , Ruchi Khanna
- 申请人： Wen Yan , Steve Huang , Minh-Thanh Nguyen , Hua (Helen) Lin , Jingqi Lei , Ruchi Khanna
- 优先权： WOPCT/US02/00107 20020102
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N5/08 ; C12N5/06
摘要：
A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and/or transplantation.
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