发明申请
US20070036715A1 Tc-labeled arylpiperazine derivatives for imaging serotonin receptor
有权
Tc标记的芳基哌嗪衍生物用于血清素受体的成像
- 专利标题： Tc-labeled arylpiperazine derivatives for imaging serotonin receptor
- 专利标题（中）： Tc标记的芳基哌嗪衍生物用于血清素受体的成像
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申请号： US11272585申请日： 2005-11-10
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公开(公告)号： US20070036715A1公开(公告)日： 2007-02-15
- 发明人: Sang Park , Hue Kwon , Seung Jang
- 申请人： Sang Park , Hue Kwon , Seung Jang
- 优先权： KR10-2005-0073622 20050811
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C07F13/00
摘要：
The present invention relates to Tc-labeled arylpiperazine derivatives for imaging serotonin receptor and, more particularly, to arylpiperazine derivatives coupled with MAMA-disulfide, N2S2 or dimethyl-N2S2 chelating ligand represented by the following chemical formula (1). New arylpiperazine derivatives according to the present invention have no problem of amide hydrolysis in metabolism and have a high affinity for serotonin receptors, and can be labeled with an optimum radionuclide of technetium, thereby being usefully applied for monitoring neurodegenerative diseases or neurological diseases of a mammal.