A system and a method for configuration and management of flash memory is provided, including a flash memory, a virtual memory region, and a memory logical block region. The flash memory includes a plurality of physical erase units. Each physical erase unit is configured to include at least a consecutive segment, and each segment is configured to include at least a consecutive frame. Each frame is configured to include at least a consecutive page. Each virtual memory region is configured to include a plurality of areas, and each area is configured to include at least a virtual erase unit. The memory logical block region is configured to include a plurality of clusters, and each cluster includes at least a consecutive memory logical block. By forming correspondence among the physical erase unit, segment, frame, page, virtual erase unit, area, memory logical block and cluster to control the data access to the flash memory, the present invention achieves the reconfiguration and management of memory consumption and access efficiency for the flash memory.