In an embodiment, a computer system comprises a processor; a memory management module comprising a plurality of instructions executable on the processor; a memory coupled to the processor; and an input/output memory management unit (IOMMU) coupled to the memory. The IOMMU is configured to implement address translation and memory protection for memory operations sourced by one or more input/output (I/O) devices. The memory stores a command queue during use. The memory management module is configured to write one or more control commands to the command queue, and the IOMMU is configured to read the control commands from the command queue and execute the control commands.