The present invention provides for oxygen scavenging materials and uses thereof for reducing oxygen content in an air cavity of a mounted tire, such as to reduce oxidation of a tire. The oxygen scavenging material can include a metal or metal-based material, an antioxidant, or microorganism. In one example, the oxygen scavenging material may be situated or secured within a tire cavity or secured to the tire rim of a wheel prior to mounting of the tire on the rim. Accordingly, the tire is mounted on the tire rim to define an air cavity with the oxygen scavenging material being located therein. The air cavity is be filled with air comprising oxygen to a desired internal air pressure with the oxygen scavenging material being provided in an amount sufficient for reducing oxygen content in the air cavity, such as to reduce oxidation of the tire thereby increasing the lifespan thereof.