发明申请
- 专利标题: METHOD FOR SULFONATION OF 1,2-BENZISOXAZOLE-3-ACETIC ACID
- 专利标题(中): 1,2-苯并恶唑-3-乙酸的硫化方法
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申请号: US11531364申请日: 2006-09-13
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公开(公告)号: US20070066830A1公开(公告)日: 2007-03-22
- 发明人: Tsutomu Ishikura , Nobuhiko Horiuchi
- 申请人: Tsutomu Ishikura , Nobuhiko Horiuchi
- 申请人地址: JP Osaka
- 专利权人: Dainippon Sumitomo Pharma Co., Ltd.
- 当前专利权人: Dainippon Sumitomo Pharma Co., Ltd.
- 当前专利权人地址: JP Osaka
- 主分类号: C07D261/20
- IPC分类号: C07D261/20
摘要:
An efficient method for the preparation of 1,2-benzisoxazole-3-methanesulfonic acid involves a reaction of 1,2-benzisoxazole-3-acetic acid in toluene with chlorosulfonic acid optionally mixed with an inert solvent in the presence of a particular Lewis base (ester or a nitrile).
公开/授权文献
- US07268234B2 Method for sulfonation of 1,2-benzisoxazole-3-acetic acid 公开/授权日:2007-09-11