A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The first spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.