Disclosed is a self-supporting tire for wheels for bicycles, motorcycles and the like comprising an outer surface layer (5), which establishes contact with the ground (8) and an inner supporting layer (6) realized by a flexible polyurethane elastomer with a cellular structure, which at least partially occupies the internal volume of the tire (1) and supports the outer surface layer, also comprising a flexible membrane (9) substantially having the shape of the outer layer (5) and radially compressing the inner supporting layer (6).