Invention Application
US20070081943A1 Alpha 4 beta 2 delta gaba-a receptors as a strategy for pms and alcoholism
有权
Alpha 4 beta 2 delta gaba-a受体作为pms和酒精中毒的策略
- Patent Title: Alpha 4 beta 2 delta gaba-a receptors as a strategy for pms and alcoholism
- Patent Title (中): Alpha 4 beta 2 delta gaba-a受体作为pms和酒精中毒的策略
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Application No.: US10566559Application Date: 2004-07-30
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Publication No.: US20070081943A1Publication Date: 2007-04-12
- Inventor: Sheryl Smith , Keith Williams
- Applicant: Sheryl Smith , Keith Williams
- Priority: US60491599 20030731
- International Application: PCT/US04/24981 WO 20040730
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
The present invention is directed to a screening mechanism for identifying members of the general population at increased risk for alcoholism and premenstrual syndrome. The screening mechanisms may be used to measure the expression of the α4β2δ GABAA receptors, in order to identify members of the general population as having an increased sensitivity to lower concentrations alcohol coupled with a decrease sensitivity to higher concentrations of alcohol, a scenario frequently found in patients suffering from alcoholism and premenstrual anxiety. Methods of screening for drugs which decrease expression of the α4β2δ subunit of GABAA are also provided.
Public/Granted literature
- US07816074B2 α4 β2 δGABA-A receptors as a strategy for PMS and alcoholism Public/Granted day:2010-10-19
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