发明申请
US20070081986A1 Beta-glucuronidase with an attached short peptide of acidic amino acids
审中-公开
β-葡萄糖醛酸酶与附着的酸性氨基酸短肽
- 专利标题： Beta-glucuronidase with an attached short peptide of acidic amino acids
- 专利标题（中）： β-葡萄糖醛酸酶与附着的酸性氨基酸短肽
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申请号： US11245424申请日： 2005-10-07
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公开(公告)号： US20070081986A1公开(公告)日： 2007-04-12
- 发明人: Shunji Tomatsu , Ken'jchi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada , Jeffrey Grubb
- 申请人： Shunji Tomatsu , Ken'jchi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada , Jeffrey Grubb
- 主分类号： A61K38/47
- IPC分类号： A61K38/47 ; C12N9/24 ; C12N9/42
摘要：
Disclosed are a fusion protein comprising enzyme β-glucuronidase and short peptide consisting 4-15 acidic amino acids attached to the enzyme on its N-terminal side, pharmaceutical composition containing the fusion protein, and a method for treatment of type VII mucopolysaccharidosis using the fusion protein. Compared with the native enzyme, the fusion protein exhibits higher stability in the blood.
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