发明申请
- 专利标题： Molecular nephrotoxicology modeling
- 专利标题（中）： 分子肾毒理学建模
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申请号： US10515325申请日： 2003-11-24
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公开(公告)号： US20070093969A1公开(公告)日： 2007-04-26
- 发明人: Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
- 申请人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
- 优先权： US10301856 20021122
- 国际申请： PCT/US03/37556 WO 20031124
- 主分类号： G06F19/00
- IPC分类号： G06F19/00
摘要：
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
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