An embolic protection device for capturing emboli during treatment of a stenotic lesion in a body vessel is disclosed. In one example, the device comprises a filter and a filter portion made of an extracellular matrix circumferentially attached to the filter. The filter comprises a plurality of struts having first ends attached together at a center portion along a longitudinal axis. Each strut has an arcuate segment extending from the first end to a second end. The struts are configured to move between an expanded state for engaging with the body vessel and a collapsed state for filter retrieval or delivery. The filter portion is configured for allowing blood to flow therethrough and for capturing emboli when the filter is in the expanded state.