发明申请
US20070105806A1 Compositions and methods for inhibiting expression of Nav1.8 gene
失效
用于抑制Nav1.8基因表达的组合物和方法
- 专利标题: Compositions and methods for inhibiting expression of Nav1.8 gene
- 专利标题(中): 用于抑制Nav1.8基因表达的组合物和方法
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申请号: US11593099申请日: 2006-11-03
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公开(公告)号: US20070105806A1公开(公告)日: 2007-05-10
- 发明人: Dinah Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- 申请人: Dinah Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; C07J17/00 ; C07H21/02 ; C12N5/10 ; C12N5/08 ; C07F9/6533
摘要:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.