发明申请
US20070112024A1 Crystal form of quinoline compound and process for its production
审中-公开
喹啉化合物的晶体形式及其生产工艺
- 专利标题： Crystal form of quinoline compound and process for its production
- 专利标题（中）： 喹啉化合物的晶体形式及其生产工艺
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申请号： US10584208申请日： 2004-12-17
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公开(公告)号： US20070112024A1公开(公告)日： 2007-05-17
- 发明人: Yoshio Ohara , Yasutaka Takada , Hiroo Matsumoto , Akihiro Yoshida
- 申请人： Yoshio Ohara , Yasutaka Takada , Hiroo Matsumoto , Akihiro Yoshida
- 专利权人： YOSHIO OHARA ET AL,NISSAN CHEMICAL INDUSTRIES, LTD
- 当前专利权人： YOSHIO OHARA ET AL,NISSAN CHEMICAL INDUSTRIES, LTD
- 优先权： JP2003-431788 20031226
- 国际申请： PCT/JP04/19451 WO 20041217
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; C07D215/12
摘要：
A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.