发明申请
- 专利标题： Process for preparation of maytansinol
- 专利标题（中）： 美登素的制备方法
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申请号： US11594156申请日： 2006-11-08
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公开(公告)号： US20070112188A1公开(公告)日： 2007-05-17
- 发明人: Wayne Widdison , Ravi Chari
- 申请人： Wayne Widdison , Ravi Chari
- 专利权人： IMMUNOGEN, INC.
- 当前专利权人： IMMUNOGEN, INC.
- 主分类号： C07D491/14
- IPC分类号： C07D491/14
摘要：
The present invention describes the preparation of maytansinol by methods that minimize processing steps, and reduce solvent volumes, making the process more efficient, and scaleable. This process comprises a step of converting bridged acetals of maytansinol to maytansinol. The simplified processing also aids in lowering the potential for human exposure to chemicals. Also provided is an isolated C3 to C9 bridged acetal of maytansinol.
公开/授权文献
- US07411063B2 Process for preparation of maytansinol 公开/授权日：2008-08-12
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