发明申请
- 专利标题: 4-Aminopyrimidine-5-thione derivatives
- 专利标题(中): 4-氨基嘧啶-5-硫酮衍生物
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申请号: US11581529申请日: 2006-10-16
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公开(公告)号: US20070117821A1公开(公告)日: 2007-05-24
- 发明人: Qingjie Ding , Nan Jiang , Allen Lovey
- 申请人: Qingjie Ding , Nan Jiang , Allen Lovey
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D403/02
摘要:
Novel 4-aminopyrimidine-5-thione derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular Cdk1, Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors.
公开/授权文献
- US07705009B2 4-aminopyrimidine-5-thione derivatives 公开/授权日:2010-04-27
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