A barrier formed from a silicone gel composition for application to the human skin to retain devices on the skin or inserted through the skin or into body orifices, the silicone gel composition forming a fluid tight seal between the skin and the applied devices. The barrier may include a stretchable matrix incorporated within the silicone gel composition so that the barrier, once elongated, will return to its original dimensions while maintaining a leak-free seal. Applications include, but are not limited to, attachment of male and female incontinence devices, ostomy devices, trancutaneous tubes, and wound care products.