发明申请
US20070122341A1 Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques
审中-公开
苯亚甲基苯胺衍生物及其放射性同位素标记化合物，用于结合和成像β-淀粉样蛋白斑
- 专利标题： Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques
- 专利标题（中）： 苯亚甲基苯胺衍生物及其放射性同位素标记化合物，用于结合和成像β-淀粉样蛋白斑
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申请号： US11424741申请日： 2006-06-16
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公开(公告)号： US20070122341A1公开(公告)日： 2007-05-31
- 发明人: Jae Min Jeong , Dong Soo Lee , June-Key Chung , Myung Chul Lee
- 申请人： Jae Min Jeong , Dong Soo Lee , June-Key Chung , Myung Chul Lee
- 申请人地址： KR Seoul
- 专利权人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
- 当前专利权人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2005-0115012 20051129
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C07D249/02
摘要：
Benzylideneaniline derivatives of formula 1 wherein R1-R5 are independently selected from hydrogen, C1-C4 alkyl and F (at least one of them is F) and each R6-R10 are independently selected from hydrogen, C1-C4 alkyl, OH, OCH3, NH2, NHCH3 and N(CH3)2 (at least one of them is OH, OCH3, NH2, NHCH3 or N(CH3)2) are disclosed. Benzylideneaniline derivatives according to the present invention have high affinity to β-amyloid plaques. Thus, they can cross the blood-brain-barrier (BBB) and bind to β-amyloid plaques after administration into the body, making them useful for treatment, prevention, or imaging of Alzheimer's disease.
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