发明申请
US20070123479A1 Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
有权
包含用于治疗b细胞相关疾病的双特异性抗cd3抗CD19抗体构建体的药物组合物
- 专利标题： Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
- 专利标题（中）： 包含用于治疗b细胞相关疾病的双特异性抗cd3抗CD19抗体构建体的药物组合物
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申请号： US10554852申请日： 2004-05-26
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公开(公告)号： US20070123479A1公开(公告)日： 2007-05-31
- 发明人: Peter Kufer , Ralf Lutterbuse , Birgit Kohleisen , Steven Zeman , Patrick Bauerle
- 申请人： Peter Kufer , Ralf Lutterbuse , Birgit Kohleisen , Steven Zeman , Patrick Bauerle
- 申请人地址： DE 81477 MUNCHEN
- 专利权人： MICROMET AG
- 当前专利权人： MICROMET AG
- 当前专利权人地址： DE 81477 MUNCHEN
- 优先权： EP03012136.2 20030531
- 国际申请： PCT/EP04/05685 WO 20040526
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K48/00
摘要：
The present invention relates to a pharmaceutical composition comprising a bispecific single chain antibody construct, said bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (VH) and the corresponding variable light chain regions (VL) regions are arranged, from N-terminus to C-terminus, in the order, VH(CD19)-VL(CD19)-VH(CD3)-VL(CD3), VH(CD3)-VL-(CD3)-VH(CD19)-VL(CD19) or VH(CD3)-VL(CD3)-VL(CD19)-VH(CD19). Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CD19 antigen are disclosed.
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