利索-全球专利检索

  1. 登录
  2. 注册
发明申请
US20070123500A1 Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds 审中-公开
ERbeta选择性物质的前体药物，其制备方法和包含这些化合物的药物组合物

  • 专利标题： Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds
  • 专利标题（中）： ERbeta选择性物质的前体药物，其制备方法和包含这些化合物的药物组合物
  • 申请号： US11604891
    申请日： 2006-11-28
  • 公开(公告)号： US20070123500A1
    公开(公告)日： 2007-05-31
  • 发明人: Gerd Mueller , Dirk Kosemund , Ralf Wyrwa
  • 申请人： Gerd Mueller , Dirk Kosemund , Ralf Wyrwa
  • 优先权： DE102005057224.3 20051129
  • 主分类号： A61K31/56
  • IPC分类号： A61K31/56 ;  C07J1/00
Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds
摘要：
The present invention makes available prodrugs of 9α-substituted oestratrienes of the general formula (I) in which the group Z is bonded to the steroid, processes for their preparation, pharmaceutical compositions which comprise these compounds and use thereof. The compounds of the general formula I according to the invention do not bind to the oestrogen receptor a and/or β. They bind to carboanhydrases and inhibit these enzymes.
摘要（中）：

本发明提供了通式（I）的9α-取代的邻三烯的前药，其中基团Z与类固醇结合，其制备方法，包含这些化合物的药物组合物及其用途。 根据本发明的通式I的化合物不结合雌激素受体a和/或β。 它们与碳水解酶结合并抑制这些酶。

信息查询
Global Dossier Espacenet
0/0