A card reader with wireless transmission comprises a circuit board and a wireless transmission control chip on the circuit board. The circuit board 11 further includes a connector for a data transmission line whose free end is provided with a plug to be inserted into a USB port attached onto a computer main board. The card reader is further provided with at least memory-card insertion slot, whereby the control chip will send and receive radio signals through a plastic case partially extended out of the outer surface of the computer, without being shielded. The card reader with wireless transmission has a further advantage of not occupying an external USB port.