发明申请
- 专利标题: CHEMOKINES AS ADJUVANTS OF IMMUNE RESPONSE
- 专利标题(中): 作为免疫应答的补充
-
申请号: US11626667申请日: 2007-01-24
-
公开(公告)号: US20070128159A1公开(公告)日: 2007-06-07
- 发明人: Alain Vicari , Christophe Caux , Drake LaFace
- 申请人: Alain Vicari , Christophe Caux , Drake LaFace
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 优先权: EPEP0974357A1 19980716
- 主分类号: A61K38/19
- IPC分类号: A61K38/19
摘要:
Dendritc cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating or inhibiting the migration or activation of antigen-presenting dendritic cells. In particular, chemokines are used to initiate, amplify or modulate an immune response. In one embodiment, chemokines are used to attract dentritic cells to the site of antigen delivery. An increase number of dendritic at the site of antigen delivery means more antigen uptake and a modified immune response.