发明申请
US20070128187A1 Reagents and method for modulating Dkk-mediated interactions
失效
用于调节Dkk介导的相互作用的试剂和方法
- 专利标题： Reagents and method for modulating Dkk-mediated interactions
- 专利标题（中）： 用于调节Dkk介导的相互作用的试剂和方法
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申请号： US11655924申请日： 2007-01-22
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公开(公告)号： US20070128187A1公开(公告)日： 2007-06-07
- 发明人: Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
- 申请人： Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
- 专利权人： Genome Therapeutics Corporation,Wyeth
- 当前专利权人： Genome Therapeutics Corporation,Wyeth
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53 ; A61K39/395 ; A61K38/17 ; C07K14/705 ; C07K16/28 ; C07H21/04 ; C12P21/06
摘要：
The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.