发明申请
- 专利标题: Novel indazole derivatives
- 专利标题(中): 新型吲唑衍生物
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申请号: US10575645申请日: 2004-10-15
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公开(公告)号: US20070129404A1公开(公告)日: 2007-06-07
- 发明人: Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
- 申请人: Masahiko Hagihara , Ken-ichi Komori , Hidetoshi Sunamoto , Hiroshi Nishida , Takeshi Matsugi , Tadashi Nakajima , Masakazu Hatano , Kazutaka Kido , Hideaki Hara
- 优先权: JP2003-354917 20031015; JP2004-270561 20040820
- 国际申请: PCT/JP04/15663 WO 20041015
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; A61K31/416 ; C07D403/02 ; C07D231/56
摘要:
An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
公开/授权文献
- US07563906B2 Indazole derivatives 公开/授权日:2009-07-21
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