发明申请
US20070134197A1 Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
失效
通过还原胺化制备的羟烷基淀粉和蛋白质的缀合物
- 专利标题： Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
- 专利标题（中）： 通过还原胺化制备的羟烷基淀粉和蛋白质的缀合物
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申请号： US11518352申请日： 2006-09-08
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公开(公告)号： US20070134197A1公开(公告)日： 2007-06-14
- 发明人: Wolfram Eichner , Michele Orlando , Norbert Zander , Harald Conradt , Frank Hacket , Klaus Langer , Ronald Frank
- 申请人： Wolfram Eichner , Michele Orlando , Norbert Zander , Harald Conradt , Frank Hacket , Klaus Langer , Ronald Frank
- 优先权： EP04005855.4 20040311
- 主分类号： A61K38/19
- IPC分类号： A61K38/19 ; A61K38/36 ; A61K38/21
摘要：
Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
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